McNamara was born in Kansas City, Missouri, the only child of Ursula and Evan McNamara. She was raised in Lee's Summit. While growing up, McNamara was an advanced student in certain subjects, resulting in her being part-homeschooled; she received her high school diploma at age 14. At age 17, McNamara graduated summa cum laude with a Bachelor of Science degree in Business Administration from Drexel University. As of November 2015, she is studying for a Master of Science degree in Applied Economics from Johns Hopkins University.
McNamara appeared in The Maze Runner film sequel, Maze Runner: The Scorch Trials, as Sonya, a co-leader of Group B. It was announced on May 6, 2015 that McNamara would be playing the lead character Clary Fray in Shadowhunters, the Freeform television adaptation of Cassandra Clare's best-selling book series The Mortal Instruments.
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